Louise Bessant, author of our Circulation title, takes a look at a controversial issue relevant to your GCSE studies
Dr Andrew Wakefield was in the news recently because of his study on the side effects of the MMR vaccine, and was described as ‘unethical’ by the General Medical Council. Meanwhile, thousands of girls have received the HPV vaccine to protect against cervical cancer, and a new vaccination against the emerging swine flu virus was given to health workers and vulnerable people last summer.
So, how do vaccines work? Vaccines ‘kick start’ your immune system. Your body is given the answer to a disease by giving it a sneak preview of the question.
Firstly, we need to know about our immune response. White blood cells patrol around our body. All types of cells have different shaped markers on them, called antigens, to make them unique. White blood cells can tell by the antigens on a cell if it is an unwelcome invader.
We fall ill with a disease as the pathogen takes hold. Our body produces white blood cells to fight it off, and we recover. Most of the white blood cells die, but some that can fight that particular disease remain in your blood.
The next time they detect the invader these particular white blood cells remember it and reproduce very rapidly. The invaders are dealt with before you become ill; you are immune. This is ‘immune memory’ and is why most people only catch diseases such as chicken pox and measles once.
But some microorganisms are too powerful and fast-acting for our bodies to deal with, and can cause severe disability or death. Vaccination prevents this by cleverly using your immune memory.
When you’re vaccinated against a disease, you are given either a small amount of the pathogen, a modified safe form of it, its antigens, or a very similar version. The white blood cells go into action, and will remember the pathogen without you contracting the disease. Your body is already defended against the disease when you meet the pathogen for the first time.
If our immune memory is so good, why do hundreds of thousands of patients receive a flu vaccine every year? It isn’t because the body has forgotten, it is because the flu virus mutates regularly and the body cannot recognise it. When a new virus emerges scientists have to work very quickly to combat the new form.
Image:alvi2047@Flickr:cc













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